concept

ISCHEMIC STROKE

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about ISCHEMIC STROKE: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

292Connections

0Hypotheses

0Analyses

20Outgoing

50Incoming

0Experiments

0Debates

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Pathway Diagram

graph TD
    ISCHEMIC_STROKE["ISCHEMIC STROKE"]
    style ISCHEMIC_STROKE fill:#1a237e,stroke:#4fc3f7,stroke-width:3px
    ISCHEMIC_STROKE -->|"causes"| Neuroinflammation["Neuroinflammation"]
    ISCHEMIC_STROKE -->|"causes"| Blood_Brain_Barrier_Disruption["Blood-Brain Barrier Disruption"]
    ISCHEMIC_STROKE -->|"upregulates"| IFI27L2A([IFI27L2A])
    ISCHEMIC_STROKE -->|"causes"| blood_brain_barrier_integrity["blood-brain barrier integrity"]
    ISCHEMIC_STROKE -->|"causes"| neuronal_cell_death["neuronal cell death"]
    ISCHEMIC_STROKE -->|"causes"| neuroinflammation["neuroinflammation"]
    Gnetupendin_A["Gnetupendin A"] -.->|"protects against"| ISCHEMIC_STROKE
    PI3K_AKT["PI3K/AKT"] -->|"regulates"| ISCHEMIC_STROKE
    Triolein["Triolein"] -->|"treats"| ISCHEMIC_STROKE
    Tissue_Plasminogen_Activator{"Tissue Plasminogen Activator"} -->|"treats"| ISCHEMIC_STROKE
    Lipid_nanoparticles{"Lipid nanoparticles"} -->|"treats"| ISCHEMIC_STROKE
    Rehmannioside_A["Rehmannioside A"] -.->|"protects against"| ISCHEMIC_STROKE
    Excitotoxicity["Excitotoxicity"] -->|"contributes to"| ISCHEMIC_STROKE
    Remote_Ischemic_Conditioning["Remote Ischemic Conditioning"] -.->|"protects against"| ISCHEMIC_STROKE
    KLF11["KLF11"] -.->|"protects against"| ISCHEMIC_STROKE
    B_glomerulata{"B.glomerulata"} -->|"treats"| ISCHEMIC_STROKE

Outgoing (20)

Target	Relation	Type	Str
Cerebral Edema	causes	disease	0.95
Blood-Brain Barrier Disruption	causes	process	0.95
Neuroinflammation	causes	process	0.95
IFI27L2A	upregulates	gene	0.90
Microglia	activates	cell_type	0.90
neuroinflammatory cascade	associated_with	process	0.90
Amyloid-beta	promotes	compound	0.85
blood-brain barrier integrity	causes	process	0.70
neuronal cell death	causes	process	0.70
Reactive oxygen species	associated_with	process	0.70
neuroinflammation	causes	process	0.70
ENDOTHELIAL CELLS	inhibits	concept	0.50
CENTRAL NERVOUS SYSTEM	associated_with	concept	0.50
ENDOTHELIAL CELLS	associated_with	concept	0.50
CENTRAL NERVOUS SYSTEM	causes	concept	0.50
NUCLEUS	associated_with	concept	0.50
ENDOTHELIAL CELLS	regulates	concept	0.50
STEM CELLS	regulates	concept	0.50
EXTRACELLULAR VESICLES	regulates	concept	0.50
MTOR SIGNALING	regulates	concept	0.50

Incoming (272)

Source	Relation	Type	Str
PI3K/AKT	regulates	pathway	0.95
GW201	protects_against	compound	0.95
116B	treats	compound	0.95
Gnetupendin A	protects_against	compound	0.95
PLAT	treats	protein	0.95
Vagus Nerve Stimulation	protects_against	process	0.95
Triolein	treats	compound	0.95
Astrocytic Glycophagy	contributes_to	process	0.93
Neuroinflammation	contributes_to	process	0.92
Zinc Finger Proteins	therapeutic_target	protein	0.90
Tissue Plasminogen Activator	treats	drug	0.90
Lipid nanoparticles	treats	drug	0.90
CLEC7A	associated_with	gene	0.90
Excitotoxicity	contributes_to	process	0.90
KLF11	protects_against	entity	0.90
B.glomerulata	treats	drug	0.90
CMPK2	contributes_to	gene	0.90
Remote Ischemic Conditioning	protects_against	process	0.90
neuroexcitotoxicity	contributes_to	process	0.90
TAZ	protects_against	gene	0.90
Nmda Receptor	contributes_to	receptor	0.90
C1Q	associated_with	entity	0.90
oxidative stress	contributes_to	phenotype	0.90
cerebral edema	associated_with	disease	0.90
Rehmannioside A	protects_against	compound	0.90
Asparagine Endopeptidase	protects_against	protein	0.90
Glymphatic Dysfunction	contributes_to	mechanism	0.90
Ruxolitinib	protects_against	drug	0.90
Middle Cerebral Artery Occlusion/Reperfusion	associated_with	process	0.85
cGAMP	treats	compound	0.85
Β-Hydroxybutyrate	treats	compound	0.85
Cgamp	treats	compound	0.85
Ceramide	associated_with	compound	0.85
C1Q	associated_with	gene	0.85
Ion Channel Dysfunction	associated_with	mechanism	0.85
Oxidative Stress	contributes_to	process	0.85
MicroRNAs	biomarker_for	biomarker	0.85
Long Non-Coding RNAs	biomarker_for	biomarker	0.85
Ion Channel Dysfunction	contributes_to	mechanism	0.85
GW201	treats	compound	0.85
Neuroinflammation	associated_with	process	0.85
LGALS9	biomarker_for	protein	0.85
Inflammation	causes	process	0.85
Inflammatory Response	contributes_to	process	0.85
TFEB	associated_with	gene	0.85
Litebamine	treats	compound	0.85
BHB	treats	compound	0.85
Colonoscopy	causes	process	0.85
Dysregulated ZFPs	drives	protein	0.85
Mrna Nanoparticles	treats	drug	0.80

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity